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Other medicine, which include rifampicin and dexamethasone, induce CYP450 isozymes and therefore improve the conversion price.

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Injectable codeine is obtainable for subcutaneous or intramuscular injection only; intravenous injection is contraindicated, as this can lead to nonimmune mast-cell degranulation and ensuing anaphylactoid response. Codeine suppositories also are marketed in certain international locations.

Pointers released through the Medical Pharmacogenomics Implementation Consortium (CPIC) advise in opposition to administering codeine to ultrarapid metabolizers, where by this genetic information is on the market. The CPIC also indicates that codeine use be averted in very poor metabolizers, because of its not enough efficacy During this team.[forty three]

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